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Yes, metformin is still first-line for many patients, especially those without significant cardiovascular or renal risk

Supplements and complementary approaches Certain supplements can support GLP-1 therapy outcomes, potentially allowing patients to maintain results at lower medication doses

Thus, for a given secondary outcome, patients were not censored if they had another event that was part of the composite outcome (other than suicide)

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For advanced type 2 diabetes with significant beta cell failure, or for type 1 diabetes, Tresiba (or another insulin) is essential and often superior to or required in addition to GLP-1 therapy

Understanding your baseline metabolism supports informed conversations with your provider about drug interactions