glp-1 agonist clinical trials Receptor Agonists as Treatments for Type 2 Diabetes Can one drug do it

These medications mimic the hormone Glucagon-like Peptide 1 (GLP-1) which helps the pancreas release insulin in response to meals, safely lowering blood sugars

In a large study of over 460,000 adults on GLP-1 RAs, vitamin D deficiency was the #1 most frequently diagnosed deficiency within the first year

[DOI] [PubMed] [Google Scholar] 197.Strain WD, et al

UK regulatory guidance (MHRA, NICE, BNF) advises against GLP-1 use whilst breastfeeding owing to lack of robust human safety studies

Thyroid concerns: Animal studies showed thyroid tumors with both medications

These conclusions were confirmed by data from a recent meta-analysis of nine large trials, which evidenced that GLP-1RAs showed a significant reduction in MACEs (RR = 0.92