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In APP/PS1 transgenic mice, (D-Ser2)Oxm, a dual GLP-1 and Gcg receptor agonist, notably improves spatial memory and synaptic plasticity, reduces A plaque deposition in the hippocampus, and modulates the PI3K/AKT1/GSK3 signaling pathway [84]

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Analysis of 11 studies of older and newer GLP-1 weight loss drugs by the University of Oxford found that patients typically lost 8kg on weight loss jabs but returned to their original weight within 10 months of stopping them

doi: 10.1016/j.diabres.2005.11.007 38 JhalaUSCanettieriGScreatonRAKulkarniRNKrajewskiSReedJet al

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