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Referral to an endocrinologist is recommended for patients who are pregnant or planning pregnancy, pediatric patients, those with nodules or goiter, discordant laboratory results, persistent symptoms despite normal TSH, or suspected myxedema coma (requiring urgent care)

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Biomarkers: Modest Signals, Unclear Meaning While the EVOKE and EVOKE+ trials missed their primary and secondary clinical endpoints, they also collected an array of exploratory biomarkers to probe potential neuroprotective effects