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Hence, GLP-1s as a class were not considered to modify the natural history of the disease as they were not anti-fibrotics. In 2024, this perception was challenged as the dual agonists tirzepatide (Mounjaro/Zepbound, Eli Lilly

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Test compounds were added to SES as indicated in the text

T lymphocyte function is modulated through inhibition of pro-inflammatory Th17 differentiation and promotion of regulatory T cell (Treg) expansion via STAT5-dependent mechanisms [42,43]