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Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have emerged as an important therapeutic class for the management of type 2 diabetes mellitus (T2DM) and obesity owing to their ability to improve glycemic control, promote weight loss, reduce cardiometabolic parameters, and have the added advantage of a low risk of hypoglycemia due to glucose-independent insulin secretion

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- - - A new Oxford meta-analysis (P04.009, EASO 2025) confirms what many clinicians have observed: stopping GLP-1 receptor agonists often leads to rapid and near-complete weight regain within 12 years