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For a long time, pharmacological interventions for obesity were only able to offer modest weight loss typically in the single digits

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GLP-1R activation inhibits NF-kB through a series of complicated actions inside the cell, but ultimately for our purposes this leads to the downregulation of multiple inflammatory cytokines, including but not limited to Tumor Necrosis Factor Alpha, (TNF-a) Interleukin 6 and 1-beta (IL6 and IL-1b) and multiple others

Conclusion: This review highlights the need for large-scale, long-term studies to establish standardized protocols and assess the safety and efficacy of GLP-1 in managing GDM, potentially expanding therapeutic options for this condition