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Neurological evaluation: In severe and selected cases, neurological exams and brain imaging such as MRI (Magnetic Resonance Imaging) may be performed to rule out structural abnormalities, signs of brain neuroinflammation and brain microvascular impairment[2]

It is thought that GLP-1RA enters the hypothalamus through the third ventricle from circulation in the CVO by binding to tanycytes near the third ventricle [63]

158 In addition, the C max and AUC of furosemide were decreased by 34% and increased by 28%, respectively

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At week 52 in PIONEER 10, the use of additional anti-diabetic use and rescue medication use was 6% to 18% and 2% to 17%, respectively, for patients in semaglutide treatment groups and 12% and 9%, respectively in the dulaglutide treatment group

Rosenstock J, Frias J, Pall D, et al