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PCOS a 10% weight reduction is sufficient for clinical improvement in PCOS symptoms including increased fertility

10.3109/07435800.2010.496761 197 PrbstelA.-K.ZhouX.BaumannR.WischnewskiS.KutzaM.RojasO

The structures reveal a common binding pocket for negative allosteric modulators, present in both GLP-1R and GCGR 3 and located outside helices VVII near the intracellular half of the receptor

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it impairs SM microcirculation, lipid oxidation, mitochondrial activity, and glucose metabolism, which might aggravate metabolic dysfunction and IR