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Reasons patients commonly switch include wanting greater weight loss after plateauing on Wegovy, experiencing intolerable side effects on one drug but not the other, or the new availability of Mounjaro on the NHS in their area, making it more accessible

From Biological Aging to Functional Decline: Insights Into Chronic Inflammation and Intrinsic Capacity

Your health goals and preferences Whether youre interested in GLP-1s or SGLT2 Inhibitors, remember that each medicine has different routes of administration, side effects, duration of action, costs, and effects on weight and A1C level

doi: 10.1200/jco.2008.16.3725 24 RochlinDHBarrioAVMcLaughlinSZee VanKJWoodsJFDayanJHet al

[PubMed] Hathaway CK, Agarwal N, Planas LG, et al

This "step therapy" approach, common in pharmaceutical benefit management, could make orforglipron the default first-line GLP-1 therapy for many patients, with injectable options reserved for orforglipron non-responders or patients with specific clinical needs for higher efficacy