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This parallels the early worsening phenomenon documented with intensive insulin therapy in landmark trials like DCCT, where temporary deterioration was followed by long-term benefits with sustained glycemic control 47

At the 12 week mark, participants were still in the dose escalation phase

GLP-1 receptor agonists mimic naturally-occurring hormones that signal fullness to the brain and slow emptying in the gut

This is likely due to the random effect model being selected for most NMA outcomes, while an ITC does not account for random effects between trials

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The SURMOUNT-1 study showed that participants lost an average of 15 to 20 percent of their body weight over 72 weeks