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Ongoing clinical trials are planned, including evaluating tirzepatide as adjunctive therapy in individuals with a BMI over 27 who are already receiving infliximab or adalimumab treatment (NCT06774079)
Research has identified multiple pathways through which semaglutide impairs normal stomach function: Direct inhibition of gastric motility through vagus nerve modulation Disruption of gastric pacemaker cells that coordinate stomach contractions Impaired gastric accommodation in the fundus and body regions Antral hypomotility preventing proper food grinding and propulsion Dysregulation of pyloric sphincter relaxation blocking stomach emptying Alterations in small intestinal motility affecting the entire digestive process Clinical data reveals that up to 75% of patients with normal gastric emptying before receiving GLP-1 agonists developed delayed gastric emptying after treatment initiation, with some studies showing 30% experiencing severe delays qualifying as gastroparesis

For example, if a patient experiences increased gastrointestinal side effects from a GLP-1 agonist while on hormonal therapy, adjustments may be necessary to optimise comfort and therapeutic outcomes

Conversely, GLP-1RAs may exert direct effects on the brain, depending on their ability to cross the bloodbrain barrier (BBB)

Online ordering and direct-to-consumer platforms offering GLP-1s for weight loss worry Dr

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