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Both semaglutide and tirzepatide are well-known for their effects on weight loss and blood sugar control, but our study suggests they may also offer substantial benefits to patients with obesity and type 2 diabetes by reducing adverse heart failure outcomes. Despite promising results from existing randomized controlled trials of semaglutide and tirzepatide in those with obesity-related HFpEF, regulatory authorities and professional societies have not approved or endorsed the use of these drugs for HFpEF, due in part to the studies relatively small sample sizes and unknown generalizability

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Am J Physiol-Endocrinol Metab (2013) 304:E67785

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Consequently, it is currently not possible to determine the correlation between adverse events experienced during the treatment period and subsequent weight regain after discontinuation

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Titration pacing matters In the Phase 2 NEJM trial, GI side effect rates nearly doubled when participants jumped to 8 mg instead of climbing gradually from 1-2 mg

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