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Recent years have also seen a surge in demand for combination therapies and next-generation multi-agonists, reflecting evolving treatment paradigms and patient preferences

Adherence and injection technique also affect outcomes

Further in vivo studies using mice demonstrated that, while Cmp2 failed to prominently enhance glucose-mediated insulin release when compared with the more potent peptidic drugs exenatide and liraglutide, it did nevertheless significantly decrease the overall glucose excursion (Irwin et al ., 2010)

Among these, sodium-glucose co-transporter 2 inhibitors (SGLT2-Is) and GLP-1RAs proved to have several vascular actions going beyond simple antihyperglycemic effects

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