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Does semaglutide actually work, or is the attention around it mostly hype

When glucose triggers -cell depolarization through K-ATP channel closure and L-type Ca 2+ channel opening (ion channels), the resulting Ca 2+ influx not only directly causes exocytosis but also can be amplified by GPCR signaling
Their liraglutide recombinant injections (Victoza and Saxenda) have patents expiring at the end of this year and in the first half of 2024

Nature Reviews Drug Discovery 24 , 902-903 (2025) doi: Competing Interests The authors declare no competing interests.

Targeting the IL-6/JAK/STAT3 signalling axis in cancer
