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The p38 MAPK/NF-B pathway as a potential target for DPN treatment [75], [77], [78]

This is why careful planning matters during treatment

Dose timing, medication interactions, weight loss speed, and concurrent stressors all warrant assessment to distinguish GLP-1-related effects from other causes

For now, both drugs are positioned as potentially transformative next-generation treatments that could offer advantages over existing single-target GLP-1 agonists

Eur J Heart Fail (2019) 21(10):12708

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