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A key finding from discontinuation studies is that the extent of rebound depends partly on individual biology

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Glucagon-like peptide-1 (GLP-1) receptor agonists have emerged as an effective second-line treatment option for patients with T2DM who are refractory to metformin therapy [7]

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Managing Side Effects and Maximizing Injection Success Nausea is the most common side effect in the first few weeks and typically improves as your body adjusts

In those with a history of severe hypoglycemia and/or hypoglycemia unawareness, however, it may be prudent to reduce the basal insulin dose to err on the side of safety regardless of their current A1C