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GLP-1 medications carry a boxed warning that has made many patients uneasy, but the warning is often misunderstood

If your primary issue is a plateau on semaglutide, a permanent switch to tirzepatide is supported by stronger evidence than alternating

A dosage-response effect must also be considered, but such studies have been very limited

UK Chief Medical Officers recommend no more than 14 units weekly, spread over several days, with some alcohol-free days each week

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They also reduce hepatic glucose output by decreasing hepatic FFA uptake and the expression of key gluconeogenesis enzymes such as PEPCK and G6Pase, while promoting hepatic sensitivity to insulin, transforming the liver from an "energy output organ" to an "energy storage organ"