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Cardiovascular and renal outcomes with SGLT-2 inhibitors versus GLP-1 receptor agonists in patients with type 2 diabetes mellitus and chronic kidney disease: A systematic review and network meta-analysis

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Optimizing concentration ranges and dosing volumes through preliminary titration assays ensures that interactions are measurable without introducing non-specific effects

Twice the injection frequency means twice the injection site management

Recurrent yeast infections despite good glycaemic control warrant GP review and possible further investigation of diabetes management

Autoimmune patients, particularly those with GI-affecting conditions or those on immunosuppressants, may benefit from a slower escalation schedule