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Description
The result: Increased glucose-dependent insulin secretion Reduced glucagon release Better control of fasting & postprandial glucose Weight-neutral therapy with minimal risk of hypoglycemia A simple yet effective mechanism that plays a powerful role in modern diabetes management

Importantly, the Ser451/452 doublet was required for GRK2 recruitment to the active GLP-1R

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GLP-1 receptor agonists may cause dizziness or lightheadedness, especially during initial titration or dose increases

Moreover, it remains to be shown that GIPR agonism can improve insulin secretion in type 2 diabetic patients who have been noted in previous studies to be unresponsive to GIP

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