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The primary endpoint for each study was the change in Hba1c from baseline except for the SURPASS J study whose primary endpoint was the number of participants with more than one severe adverse event

With tirzepatide, this may happen after 36 months of steady weight loss, particularly if you've already reached a new equilibrium

On average, patients lost about 40 pounds while on GLP-1 therapy

The answer is the same no matter why you want semaglutide, but there can be different specifics that they'll look at if you're getting the medicine for obesity than if you're getting it for diabetes

doi: 10.1146/annurev-animal-021419-083626

A patient who started semaglutide for weight management may have also reduced their alcohol intake or stopped smoking as an additional result