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Non-GLP-1 weight loss medications offer alternatives for patients unable to tolerate GLP-1-related gastrointestinal effects

The trial escalation tables stepped the amount up on a monthly cadence, beginning in the low single-digit milligram range and only advancing once the prior level felt comfortable

If insomnia persists beyond 12 weeks despite implementing all the strategies in this guide, a medical evaluation is warranted

Instead, it works through a fundamentally different mechanism

Delaying digestion: Slower gastric emptying keeps you feeling fuller for longer periods

GLP-1 receptor agonism is well established to slow gastric emptying, which can increase intra-gastric pressure and potentially promote acid reflux in susceptible individuals