glp 1 and arthritis GLP-1s for Rheumatoid Arthritis: Can These Weight Loss Drugs Help With RA? Targeting the GLP-1/GLP-1R axis to

Emmerich SD, Fryar CD, Stierman B, Ogden CL

Key Takeaways GLP-1 nausea is common but manageable with the right strategies

The recurrence of symptoms in certain patients has been observed when reintroducing either the same drug or another from the same class [165]

The addition of basal insulin to metformin for dual therapy is considered the highest efficacy option according to the ADA Standards of Care

Pyrimidinedione derivatives, known for enhanced metabolic stability, led to the potent, selective, and bioavailable DPP-4 inhibitor alogliptin

There is great variety amongst the class of GLP-1 agonists regarding their pharmacokinetic properties (Table 1)