glp-1 drugs and depression Glucagon-like peptide-1 receptor agonists risk of suicidality among patients with type 2 diabetes: active comparator, new user cohort study Researchers find GLP-1 medications safe

(accessed May 2013) 71.European Medicines Agency (EMA) Investigation into GLP-1-based diabetes therapies concluded

Accessed April 29, 2026

Key Companies in GLP-1 Analogues Market AstraZeneca Bristol-Myers Squibb Company D&D Pharmatech Eccogen Eli Lilly and Company Glenmark Pharmaceuticals Ltd

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Patients were being treated with metformin-based background therapy and were considered at high risk for a cardiovascular event [56]

Conclusions Evidence accrued so far suggest that GLP-1RA could exert a modest renal benefit alongside CV protection, justifying its place as second-line drug in patients with T2D and CKD not achieving glycemic control with SGLT-2i and metformin according to KDIGO guidelines [87]