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Both authors declare that they have no conflicts of interest

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By limiting the most probable DPP-8-selectivity imparting modification points in DPP-8/9 inhibitors to areas of space that are topologically similar to the piperazine ring, this strategy may serve as a useful platform for developing future selective DPP-8 inhibitors, including novel chemotypes

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Articles were reviewed for efficacy at reducing A1c (Tables 1 and 2) or for other clinical effects including effect on weight, blood pressure (BP), or other drug-related outcomes

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