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These can counteract semaglutides weight loss effects

Compounded GLP-1 Therapy does not only activates GLP-1 receptors but also acts as a GIP (glucose-dependent insulinotropic polypeptide) to help control appetite and blood sugar, which could lead to greater weight loss

doi:10.1186/s10194-022-01402-2

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Also, berberine may interact with medications and is not recommended for people who are pregnant or who have liver issues

What are the potential side effects, and how can they be managed
