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For GLP-1 analogs, meta-analyses have shown that women tend to experience greater weight loss than men, with a mean difference of approximately 1 kg, potentially due to sex-specific differences in GLP-1 receptor expression and hormonal interactions.[55] This more favorable response in women may also be attributable to interactions between estrogen and GLP-1, as demonstrated by preclinical studies in mice.[56,57] Regarding MSTN inhibition, sex-based variation has been reported in both circulating MSTN levels and physiological responses

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Early clinical trials evaluating the efficacy of GLP-1 receptor agonists reported a slightly increased risk of acute pancreatitis with these medications versus placebo or conventional treatment