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Its role as a glucagon-like peptide-1 (GLP-1) agonist involves influencing appetite and insulin secretion

Iron, vitamin D, and calcium also demand attention: iron deficiency causes fatigue and impairs metabolism, while vitamin D supports immunity and bone health during weight loss

The SURMOUNT trials demonstrated tirzepatide at 15 mg achieving 15% to 21% body weight loss by week 72, about 17 months

These medications are usually prescribed to adults with a BMI over 30 or over 27 with related health conditions

However, these remain rare events, and causality is difficult to establish due to confounding factors such as co-existing gastrointestinal conditions, previous surgeries, or underlying inflammatory bowel disease

This TDEE calculator uses the formulas from the Eli Lily Surmount studies published in the New England Journal of Medicine and displays your score in a way that's easy to read and meaningful to your journey