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A common threshold: pause the protocol if resting heart rate exceeds 100 bpm sustained for more than 48 hours, or if the subject experiences symptomatic palpitations not explained by exertion or anxiety

Context and Comparison The HISTORI trial adds to a modest (but growing) body of research exploring GLP-1 receptor agonists in psychiatric populations

doi: 10.1016/j.jconrel.2023.10.041

FDA is actively working on resolving that shortage

These findings suggest that rapid weight loss on these medications may come with a structural cost that standard follow-up appointments aren't always designed to catch

I aim for 140 to 150 grams a day