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In addition, it can also activate the UCP1 protein in brown adipose tissue (BAT), increase heat production, and achieve a transition from "energy wasting" metabolism (such as shivering heat production) to "efficient utilization" metabolism

[DOI] [PubMed] [Google Scholar] [15].Menghini R, Casagrande V, Rizza S, Federici M

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The clustering of Cardiovascular, Renal, Adipo-Metabolic Eye and Liver disease with type 2 diabetes

Lean chow-fed male C57BL/6 J mice were single-housed in cages equipped with a running wheel and allowed 3 days of habituation before being treated with once-daily s.c