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Compounded tirzepatide products have not been FDA-approved, and their safety and efficacy have not been evaluated by the FDA

Most people receiving compounded tirzepatide with B12 expect a clear liquid, similar to what they see in advertisements for brand-name pens

Here are the five most significant concerns, ranked by clinical severity

Most patients regain weight after stopping tirzepatide

A clinical trial conducted in May 2025 observed patients taking either drug for 72 weeks, looking closely at their percent change in weight

[3] The exact way they work to help you lose weight isnt completely understood, but scientists believe they helps slow the movement of food from your stomach, making you feel full for longer