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(2022, Cell Metabolism) is the pivotal discovery and characterization paper

By 2024, an estimated 12% of American adults reported taking a GLP-1 medication for diabetes, weight loss, or heart disease, according to data from the Kaiser Family Foundation

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This dual effect makes GLP-1 receptor agonists effective for blood sugar regulation in diabetes and as weight loss medications

Findings This cohort study emulated target trials among 1 511 637 eligible patients with type 2 diabetes by comparing treatment with either semaglutide or tirzepatide vs other antidiabetic medications

Side effects peaked at weeks 6-8 and resolved by week 12 for the majority