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Reduces appetite aids weight loss Common Drugs (Examples) Exenatide Liraglutide Dulaglutide Semaglutide Lixisenatide Clinical Uses Type 2 Diabetes Mellitus (as monotherapy or combination) Obesity / weight management (especially semaglutide, liraglutide) Cardiovascular benefit: reduces major adverse CV events in T2DM with CVD Administration Subcutaneous injection (daily or weekly depending on formulation) Oral semaglutide available for some patients Adverse Effects Gastrointestinal: nausea, vomiting, diarrhea Risk of pancreatitis (rare but serious) Mild hypoglycemia if combined with sulfonylureas or insulin Injection site reactions Contraindications / Precautions Personal/family history of medullary thyroid carcinoma History of multiple endocrine neoplasia syndrome type 2 (MEN2) Severe gastrointestinal disease (gastroparesis) GLP-1 agonists = incretin mimetics

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Weight Management Advanced Appetite Control &amp

Donovan includes a thought-provoking assessment of the effects of the GLP-1s in equality and society, calling out that, In most societies there is prejudice against people who are overweight or obese, more pronounced the case for women The more anti-obesity drugs are used recreationally rather than as a prescription written for obesity, the more likely patients will have to pay for the drugs out-of-pocket restricting recreational access to people with higher incomes Social media has raised the importance of physical appearance and for some people increased the perceived importance of appearances

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