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100102 In addition, inflammatory cytokines are reportedly involved in CYP gene expression, with the reduced cytokine levels-mediated by GLP-1 RA administration may alter CYP gene expression, potentially leading to changes in the pharmacokinetics of co-administered drugs (Figure 3)

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While preliminary studies and observational signals suggest potential thyroidal effects, no RCTs have evaluated progression of Hashimoto thyroiditis or Graves disease under GLP-1RA therapy [32,58]

A comparative transcriptomic analysis of glucagon-like peptide-1 receptor- and glucose-dependent insulinotropic polypeptide receptor-expressing cells in the hypothalamus

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This timing reduces gastric contents and aspiration risk during anesthesia