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The FDA's Zepbound prescribing information specifically warns about acute kidney injury secondary to dehydration from prolonged GI side effects most cases are uncomfortable but not dangerous, but a small percentage need urgent medical care, and knowing the difference matters more than any single management tip

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Schmidt PT, Ljung T, Hartmann B, et al

Clinical efficacy and safety of sodium-glucose cotransporter protein-2 (SGLT-2) inhibitor, glucagon-like peptide-1 (GLP-1) receptor agonist, and Finerenone in type 2 diabetes mellitus with non-dialysis chronic kidney disease: a network meta-analysis of randomized clinical trials