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The pharmaceutical industry has already developed dual agonists targeting both GLP-1 and GIP (glucose-dependent insulinotropic polypeptide) receptors

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et al., provide evidence that in patients with T2DM, SGLT-2 inhibitors significantly reduce, though to different extents, visceral adipose tissue, subcutaneous adipose tissue, and ectopic liver fat

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The rationale for the recent study was that while we know weight loss alleviates symptoms of knee osteoarthritis, the effect of GLP-1 receptor agonists was yet to be explored