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Lancet (London, England) 392(10157):15191529 Lam CSP, Ramasundarahettige C, Branch KRH, Sattar N, Rosenstock J, Pratley R, Del Prato S, Lopes RD, Niemoeller E, Khurmi NS et al (2022) Efpeglenatide and clinical outcomes with and without concomitant sodium-glucose cotransporter-2 inhibition use in type 2 diabetes: exploratory analysis of the AMPLITUDE-O trial

The 3-pen package covers the first 4 weeks of titration plus 4 doses of 3 mg

eating regular breakfast

55 GLP-1 RAs appear to quiet this internal chatter, potentially by modulating reward pathways in the brain associated with food, making highly palatable foods less enticing and reducing the constant mental preoccupation with eating

These pathways affect significant processes linked to aging and extend beyond merely regulating glucose metabolism

This makes sense because the body is adjusting to stronger digestive and appetite signals
