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Cardiovascular benefit for GLP-1RAs was shown in 2016 for liraglutide in the LEADER trial and semaglutide in the SUSTAIN 6 trial

[DOI] [PMC free article] [PubMed] [Google Scholar] 688.Sisley S., Gutierrez-Aguilar R., Scott M., D'Alessio D.A., Sandoval D.A., Seeley R.J

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Further investigations illustrated that GLP-1 robustly stimulates IGF-1R expression and Akt phosphorylation (39), which in turn maintain pancreatic mass