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Metformin, a first-line T2DM treatment, affects the gastrointestinal tract by altering glucose uptake, GLP-1 secretion, gut microbiota, and immune response [33, 34], but it rarely causes bowel obstruction

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Lancet 140-6736(23): 01200-X

Berberine may lower blood sugar through a couple mechanisms

CrossRef The Predictive Value of Insulin Resistance Surrogates for Diabetic Kidney Disease in Type 2 Diabetes Mellitus Qiuying Sun, Meiru Zhao, Xiaonan Wang, Jiangteng Wang, Yaxi Yang, Lin Liu, Di Zhu, Xu Li, Qingbo Guan, Xu Zhang Diabetes Therapy.2025

Reduz o glucagon diminui a liberao de glicose pelo fgado
