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Self-assembling -sheet peptide nanofibers displaying GLP-1 epitopes form injectable hydrogels (storage modulus 1.2 kPa) capable of co-encapsulating islets [169]

However, neuronal ROS production was reduced, while astrocytic ROS levels increased, suggesting possible differential effects on mitochondrial function [85]

The authors noted that the studys design, while robust in terms of follow-up length and population diversity, was limited by the absence of hemoglobin A1c measurements and by the lack of GLP-1RA medications during participants follow-up period

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[DOI] [PMC free article] [PubMed] [Google Scholar] 44.Skibicka KP, The Central GLP-1: Implications for Food and Drug Reward, Frontiers in Neuroscience 7 (2013): 181
