cagrisema cagrilintide semaglutide phase 3 results 2024 2025 combination Once-weekly cagrilintide for weight management in people with overweight and obesity: a multicentre, randomised, double-blind, CagriSema Outperforms Semaglutide Alone Across

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2025;79 doi: 10.1016/j.eclinm.2024.103020

Securing supply for these blockbusters has been high on the agenda for both Eli Lilly and fellow GLP-1 developers, including Novo Nordisk, which reported 2023 sales from its own diabetes and weight loss semuglatide products Ozempic and Wegovy of $13.7 billion and $4.5 billion, respectively