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doi: 10.1038/s41598-018-22962-x 99 WangPYJinC-CLiuCZhaoZ-JYangH-Y

The index event was IBS-D diagnosis and medication initiation

Indeed, previous reports indicate that GLP-1R signaling is blunted when dynamin-dependent endocytosis is inhibited chemically 10 or genetically 56

Almost 30% of adults age 65 and older have a BMI of 30 or higher
Requires larger volumes for higher doses, which can be less comfortable to inject
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For instance, GLP-1 RAs appear to reduce inflammation in the ovaries and may help lower androgen levels ( 10 , 12 ), indicating potential broader effects on reproductive and metabolic health
