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4ac), revealing the essential role of CNS GIPR for the maximal weight loss response to combined GIPR blockade/GLP-1R activation

Most gastrointestinal side effects occur during dose escalation and reduce significantly over time

Human evidence - Phase 2 MASLD substudy (Sanyal et al., Nature Medicine 2024) Adults with MASLD and at least 10% liver fat
physiology 301 (4), R1011R1024

The two things I did consistently to get here are: 1
