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95% CI: 0.26 to 0.08

In humans, the anorectic effect of GLP-1 was disappeared after truncal vagotomy (60), suggesting that vagal afferents are related to mediating the satiating effects of GLP-1

In contrast, tirzepatide showed a statistically significant reduction (MD: 1.95 mmHg

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In a phase II study of the long-acting GLP-1RA efpeglenatide (4 mg once weekly, 6 mg once weekly, 6 mg once every 2 weeks, and 8 mg once every 2 weeks), patients with obesity and without diabetes had statistically significant reductions in body weight compared with placebo after 20 weeks of treatment (differences in least squares means were 6.3 to 7.2 kg

Tirzepatide vs semaglutide thigh injections Both medications are subcutaneous injections targeting the same tissue layer