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The choice also involves practical considerations

Is it safe to eat very few calories on GLP-1 medication

Mitchell JL, Mollan SP, Vijay V, Sinclair AJ

Wegovy (semaglutide) is a GLP-1 receptor agonist used to help obese adults lose weight

To assess the robustness of our findings against unmeasured confounding, we calculated E-values for both primary and secondary outcomes 39

These include: Nausea and vomiting typically most pronounced during dose escalation and often improving with continued use Diarrhoea or constipation affecting bowel habit regularity Abdominal pain and discomfort ranging from mild cramping to more significant discomfort Dyspepsia and gastro-oesophageal reflux related to delayed gastric emptying Injection site reactions are classified as 'common' (affecting up to 1 in 10 people) and may include redness, itching, bruising, or localised swelling at the subcutaneous injection site
