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Safety Considerations When Combining Both Medications The combination of semaglutide and metformin has not been associated with major drug-drug interactions in clinical practice or pharmacological studies

These include pancreatitis, hypersensitivity reactions requiring close monitoring under a doctors care during treatment and possibly thyroid carcinoma

The trials were not designed to detect a difference in terms of these outcomes, and none of the analyses were controlled for multiplicity

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6 Grades of histopathological NASH features corresponding to animals in Figs

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