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Semaglutide 24 mg once a week in adults with overweight or obesity, and type 2 diabetes (STEP 2): a randomized, double-blind, double-dummy, placebo-controlled, phase 3 trial

Materials and methods Antibodies and reagents PC2 antibody (D1E1S), t-PKA antibody (D38C6), p-PKA antibody (D45D3), Pdx1 antibody (D59H3), GLP-1R antibody (HA500204) and all secondary antibodies used in Western blot were purchased from Cell Signaling Technology (Beverly, MA, United States)

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Because its insulin-boosting effect is glucose-dependent, Ozempic works for type 2 diabetes by only ramping up insulin production when blood sugar is already elevated

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