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(2024, December 19)

Remember that tirzepatide carries a boxed warning and is contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2)

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Amritha CA, Kumaravelu P, Chellathai DD

Clinical Implications Beyond Diabetes and Obesity While retatrutide is being tested primarily for obesity and type 2 diabetes , its impact on LDL suggests future use in: Cardiovascular disease prevention (alongside statins or in statin-intolerant patients) Metabolic syndrome management Nonalcoholic fatty liver disease (NAFLD/NASH) , since LDL and triglyceride metabolism are central to liver health Complementary to Statins Unlike statins, which only reduce LDL synthesis, retatrutide may work through multiple lipid pathways , making it synergistic rather than redundant

However, the process of securing these prescriptions safely through delivery services poses various challenges, encompassing legality concerns, security measures, and the potential health risks