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Advances in cardiac regeneration are highlighted by the transplantation of pluripotent stem cells, direct reprogramming, stimulation of endogenous adult cardiomyocyte proliferation, and noncell strategies, all of which aim to restore cardiac tissue integrity

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This article reviews clinical mechanisms, biomarker considerations, and how genetic factors may contextualize individual responses

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An underrated element of these diseases is that glucose uptake and energy utilization is much reduced in neurons