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It's administered as a once-weekly injection under the skin, typically in the stomach, thigh, or upper arm

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How GLP-1 Agonist Injections Work GLP-1 Agonist, commonly known under the brand name WegovyTM, is an injectable glucagon-like peptide-1 (GLP-1) receptor agonist

There are primarily two types of GLP-1 agonists, which are as follows: (1) Short-acting GLP-1 receptor agonist: This class of agonists is identified by brief spikes in plasma drug concentrations following each injection, followed by sporadic intervals of very zero concentrations

Ghrelin acts on reward-related pathways by stimulating dopamine neurons in the ventral tegmental area and promoting dopamine turnover in the nucleus accumbens, a region of the ventral striatum ( Preclinical models indicate that the GLP-1 R system has evolved, at least in part, to regulate feeding-related motivation ( Repeated dosing is probably crucial for positive effects in depression and suicidality